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. 2016 Oct 27;7:496. doi: 10.3389/fphys.2016.00496

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Copyright © 2016 Jousset, Maguy, Rohr and Kucera.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Conduction in CMC strands with CMC-sized coating MFBs. (A) Structure of a computer-generated tissue and maps of the corresponding RMP, activation time (isochrone interval: 0.5 ms) and dV/dt_max. Coating MFBs (MFB density: 23%) are shown in green. In the maps, MFB cell borders are outlined in gray. (B–D) Effects of increasing MFB density on conduction velocity, mean RMP and mean dV/dt_max (black: individual results; green: mean ± SD, n = 5; red data point corresponds to the simulated tissue shown in A).