Figure 2.

Liver-selective mINDY-specific siRNA approach. (A) Schematic of the mouse experiment. (B) mRNA expression of indicated genes in liver of clamped mice normalized to GAPDH (n = 7, two-tailed Student's t-test with Welch's correction). (C–E) Body composition measurement for fat mass (C), free fluids (D), and lean mass (E) at start (0 wk), after 5 weeks (5 wk) and before catheterization (7 wk) (n = 16). (F) Weight gain during intervention (n = 16). Data represent mean ± SEM. Black arrows: Recording of body weight/siRNA injection, Grey arrows: Procedures: BC: Body composition, MCA: Metabolic cage analysis, OP: Catheterization.