Figure 4.

Improvement of insulin sensitivity with mINDY-specific siRNA during HE clamp. (A) Blood glucose (top) at basal and insulin-stimulated phase and according glucose infusion rate (GIR, bottom) to maintain plasma glucose at 120 mg/dl. (B) Insulin-mediated reduction of plasma NEFA. (C) Endogenous glucose production (EGP). (D). Suppression of EGP. (E) Whole-body glucose uptake during steady state. (F) 2-DG uptake of SKM (Gastrocnemius) and epididymal WAT. Data represent mean ± SEM. n = 7. Two-tailed Student's t-test with Welch's correction.