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Chemical modification of siINDY improved its pharmacokinetic properties.
| siRNA | siINDY* (unmodified) | siINDY |
|---|---|---|
| IC50KD (nM) | 0.15 | 0.56 |
| ImaxKD (%) | 92 | 92 |
| Serum stability (h): t1/2 in 50% mouse serum | <2 | 4 |
| Cytotoxicity (%): Viability of Hepa1c1c7 cells | 78 | 135 |
| Immune stimulation (pg/ml): IFNα release PBMCs | 2144 | 70 |
ImaxKD: maximal knockdown of mINDY mRNA expression.
