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. 2016 Oct 13;2016:3486727. doi: 10.1155/2016/3486727

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Copyright © 2016 Angela J. Westover et al.

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

PMC Copyright notice

Analysis of circulating levels of TNFα was completed for MET03 and MET04 before each treatment (pretreatment), immediately after each 6-hour treatment period (posttreatment), and day 1, week 1, and week 2 following the third treatment. A decrease in TNFα was consistently observed from pretreatment to posttreatment, with high significance achieved (p < 0.003^∗) when averaging all pretreatment (A, B, and C) levels (n = 9) and comparing to all posttreatment (A, B, and C) averaged levels (n = 9), providing strong evidence that SCD therapy is able to reduce the chronic systemic inflammation associated with MetS as presented in this model.