Table 3. Inhibition of LPS-stimulated NO production by PTP inhibitors in microglial cells (IC50, µM).

Target PTPs	NO reduction IC50 (μM)
PTP1B	10.6
TC-PTP	17.68
SHP2	6.08
MEG2	22.92
LYP	1.87
RPTPβ	15.1

BV-2 microglial cells were treated with LPS (100 ng/ml) in the presence of 1, 2, 5 and 10 µM of PTP inhibitors for 24 h. The nitrite content was measured using the Griess reaction.