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Inhibition of Wnt/β-catenin signaling reduces the gene expression of early differentiation markers. Shown are results of qRT-PCR–based analysis of gene expression in naïve ELF1 hESCs cultured on Matrigel with the indicated small molecules for 3 d. Fold changes were normalized to the value in DMSO-treated samples (mean + SEM of n = 3 biological replicates; *P < 0.05 by t test; n.s., not significant; expression of PAX6 is under the detection threshold).
