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. 2016 Oct 3;113(42):11919–11924. doi: 10.1073/pnas.1611421113

Table S4.

Specificity and sensitivity based on CD8 T-cell clonal expansion

No. expanded clones or more Model predicted probability of irAE % True positives detected (sensitivity) % Negatives found as positive (1 − specificity)
55 0.10 100% 42%
65 0.13 89% 38%
97 0.24 78% 19%
133 0.42 67% 12%
157 0.56 56% 4%

Logistic regression model: log(p1p)=3.4508+0.0235×(CD8NExpandedClones).