Table S4.
Specificity and sensitivity based on CD8 T-cell clonal expansion
No. expanded clones or more | Model predicted probability of irAE | % True positives detected (sensitivity) | % Negatives found as positive (1 − specificity) |
55 | 0.10 | 100% | 42% |
65 | 0.13 | 89% | 38% |
97 | 0.24 | 78% | 19% |
133 | 0.42 | 67% | 12% |
157 | 0.56 | 56% | 4% |
Logistic regression model: