Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Representative traces of whole-oocyte currents. Currents were recorded with a two-electrode voltage clamp from whole oocytes expressing (A) WT TRPV4, (B) GOF mutant W733Q, (C) GOF mutant L596I, and (D and E) the conservative mutants L596V and L596F. (F–J) Currents from oocytes expressing LOF TRPV4 mutant L596A, L596W, L596G, L596Q, and L596K. (K) L596A currents after the application of 1 μM GSK (note current scale change). All oocytes were injected with 5 ng cRNA, except those marked.
