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Administration of AdoMet had no effect on AdoHcy levels of WT or sam1Δ cells. Quantification of intracellular AdoMet and AdoHcy levels of WT (A) or sam1Δ cells (B). Mean ± SD (n = 3); ns, not significant; ***P < 0.001 (two-way ANOVA with Tukey’s multiple comparisons test).