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Superantigen mimetic peptide blocks B7-2 signaling. (A and B) p12B inhibits sB7-2/αCD3-mediated induction of IFN-γ mRNA, but not of IL-10. Human PBMCs were incubated with αCD3 monoclonal antibody (0.1 μg/mL), sΒ7-2 (1 μg/mL), or both, with or without p12B (10 μg/mL). mRNA was quantitated by RNase protection analysis; β-actin mRNA indicates equal loading of RNA (A). Secreted IL-10 was determined (B).
