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SEB uses its β-strand(8)/hinge/α-helix(4) domain to bind B7-2. (A and B) Representative SPR responses for binding of B7-2-Fc in twofold increments from 0.031 μM to immobilized p12C (YNKKKATVQELD) (A) or randomly scrambled p12Csc (EKAKYTQLVKDN) (B). (C) Mutation of SEB β-strand(8)/hinge/α-helix(4) domain peptides reduces binding of B7-2. SPR responses to 2 μM B7-2-Fc are compared for immobilized p12C, p12YK (ANAKKATVQELD), and p12KD (YNAKKATVQELA) (underlined residues were mutated).
