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Peptide mimetics of the B7-2 dimer interface protect mice from lethal SEB challenge. (A) Mice (n = 5 per group) were injected with SEB (10 μg) alone or together with 1 μg of pB2-4 or pB2-6; P for survival, 0.022. (B) Mice (n = 6 per group) were injected with SEB (10 μg) alone or together with 0.2 μg of pB2-7; P for survival, 0.005. (C) Mice (n = 10 per group) were injected with SEB (5 μg) alone or together with 1 μg of pB2-2.
