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Peptide mimetics of the B7-2 homodimer interface are superantigen antagonists. Peptides pB2-4 and pB2-6 antagonize induction of IL-2 and TNF-α by SEB. PBMCs were activated by SEB (10 ng/mL) in the absence (open circles) or presence (filled circles) of 0.1 μg/mL peptide as shown. Secreted IL-2 and TNF-α were determined. Colors correspond to those in Fig. 4B. Data are from the experiment shown in Fig. 4D.
