Fig. S10.
Tumors driven by NICD1 in combination with other pathways altered in prostate cancer are castration resistant. (A) Images of the transplanted tumors driven by NICD1/kRasG12D plotted in Fig. 6A. (Scale bars: 1 cm.) (B) NICD1/kRasG12D or NICD1/Myc tumor cells (6 × 105) were mixed with Matrigel and were transplanted s.c. into six castrated or six intact recipient mice. Upon detection of palpable tumors (50 mm3), tumors volumes were measured and plotted. (C) Histology of NICD1/kRasG12D, NICD/myrAKT, and NICD1/Myc tumors recovered from intact or castrated recipients. (Scale bars: 100 microns.)