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. 2016 Sep 30;113(42):E6457–E6466. doi: 10.1073/pnas.1614529113

Fig. S11.

Fig. S11.

γ-Secretase inhibition delays prostate cancer tumor growth. (A) 22Rv1 cells (1 × 106) were injected s.c. in NSG mice. Upon detection of palpable tumors, animals were treated with either vehicle (n = 4) or DAPT (GSI-IX) (n = 4) administered for 20 d according to the following schedule: 50 mg/kg DAPT for 3 d followed by 1 d off DAPT, then 50 mg/kg DAPT for 6 d and 1 d off DAPT. Day 1 is the day of treatment initiation. (B) Inhibition of Notch1 by DAPT in vivo was confirmed by Western blot for NICD1 and the cleaved Notch1 expression level.