Fig. 1.

Heatmaps of differentially methylated sites of peripheral blood mononuclear cells in RRMS patients vs. the healthy group (A), PPMS patients vs. healthy group (B), and PPMS patients vs. RRMS patients (C). Top panel. Dendrogram showing the results of hierarchical sample clustering. Green color indicates DNA samples from RRMS patients; blue color, from PPMS patients; black color, from healthy individuals. Left panel. Dendrogram showing the results of hierarchical DMS clustering. The intensity of grey indicates DMS localization in the genome (black color, CpG-islands, dark grey, CpG-shores, light gray, CpG-shelves). Right panel. Samples labeling based on Human Methylation450BeadChip standard annotation. RRMS, relapsing-remitting multiple sclerosis; PPMS, primary progressive multiple sclerosis.