Table 2.

Localization of differentially methylated sites (DMSs) identified in a comparative analysis of DNA methylation of PBMCs from patients with different clinical courses of MS and healthy individuals (controls), regarding the CpG-islands of the human genome

DMS localization	Number of DMS for different comparisons between the groups
	RRMS vs control	PPMS vs control	PPMS vs RRMS
Any (total DMSs)	30 (100%)	67 (100%)	51 (100%)
In CpG-island	15 (50%)	42 (63%)	27 (53%)
In CpG-shore	3 (10%)	11 (16%)	9 (18%)
In CpG-shelf	6 (20%)	2 (3%)	5 (10%)
In open sea	6 (20%)	12 (18%)	10 (19%)

Note. Localization of individual CpG-sites in the CpG-island was determined using the UCSC-annotation, version hg19; CpG-shore is located up to 2 kbp from the CpG-island; CpG-shelf – up to 2 kbp from the CpG-shore; areas not related to the above three categories are designated as “Open sea.”