TABLE 4.

Cross-correlation between each variable and 5 main nodes of the PLS path modeling analysis¹

	Diarrhea	Calprotectin	SCFA	Systemic inflammation	Death
Diarrhea	1	−0.22	−0.30	0.35	0.34
Calprotectin	−0.22	1	0.03	0.24	0.17
SCFA
Propionate	−0.28	0.04	0.97	−0.32	−0.35
Butyrate	−0.30	0.02	0.98	−0.38	−0.40
Systemic inflammation
GCSF	0.25	0.24	−0.25	0.71	0.33
IL1RA	0.11	0.25	−0.42	0.76	0.45
IL6	0.23	0.17	−0.20	0.64	0.33
IL2	0.19	0.09	−0.24	0.72	0.45
TNF-α	0.30	0.13	−0.12	0.38	0.29
TNF-β	0.23	0.13	−0.16	0.61	0.32
IL13	0.02	0.05	−0.20	0.45	0.37
IFNα2	0.43	−0.04	−0.16	0.59	0.33
IL12p70	0.22	0.22	−0.20	0.63	0.25
Death	0.34	0.17	−0.39	0.56	1

¹Cross-correlation estimates between diarrhea, calprotectin, SCFAs, markers of systemic inflammation, and death. SCFA is a composite variable of both propionate and butyrate; systemic inflammation is composed of the most robust cytokines associated with either death or diarrhea as obtained through feature selection (n = 9). Cross-correlation values are between 0 and 1 and indicate the correlation between each variable and model nodes (i.e. diarrhea, calprotectin, SCFAs, systemic inflammation, and death). GCSF, granulocyte-colony stimulating factor; IFN, interferon; PLS, partial least squares; SCFA, short-chain fatty acid.