Table 1.
Marker expression in dental MSCs (SHED, DPSCs, and SCAP) and factors identified in their secretomes.
| Dental MSCs | Positive markers | Negative markers | Factors in secretome involved in angiogenesis | Factors in secretome involved in neurogenesis |
|---|---|---|---|---|
| Stem cells from Human Exfoliatd Deciduous teeth (SHED) | CD90, CD73, CD105, CD146, STRO-1, CD44, CD13 Nestin, DCX, βΙΙΙ-tubulin, NeuN, GFAP, S-100, A2B5, CNPase Nanog, Oct3/4, SSEAs (-3, -4) |
CD11b CD45 CD34 CD14 CD19 CD43 |
VEGF-A, VEGF-C, EG-VEGF (PK-1), HGF, IGF-1, FGF-2, SDF-1, SCF, EGF, TIMP-1, -2, MMP-2, -3, -9, MCP-1, ANG, TGF-b | BDNF, GDNF, MCP-1, ED-Siglec-9, IL-6, NRCAM, GDF-15, NCAM-1, TACE, Nidogen-1 NRG-1, TIMP-1, -2, HGF, SCF, MMP-2, -3, -9, decorin, IL-22, IL28A, IL-29, osteopontin, SCF, ANG, VEGF-A, EG-VEGF, VEGF-C, growth hormone, insulin, PIGF, TGF-b |
|
| ||||
| Dental Pulp Stem Cells (DPSCs) | CD90, CD73, CD105, CD146, STRO-1, CD106, CD29, CD49, CD51, CD61, CD166, ALDH1, 3G5, CD44, CD9, CD10 CD13, CD59, MSCA-1, CD81, CD24 CD271/NGFR, Nestin, DCX, βΙΙΙ-tubulin, NeuN, GFAP, S-100, A2B5, CNPase, musashi-1, p75, snail-1, -2, slug, Sox-9 Nanog, Oct3/4, SSEAs (-1, -3, -4, -5), Notch-1, -2, -3 |
CD45 CD34 CD14, CD19 CD31, CD117, CD133 HLA-DR |
VEGF, uPA, IL-8, TSP-1, IGFBP-3, TIMP-1, -4, MMP-9, PAI-1 (serpin E1), endostatin, ANGPT-1, ANG, DPPIV, EDN-1, PTX-3, PEDF (serpin F1), PDGF-AA and PDGF-AB/BB, MCP-1 | NGF, BDNF, NT-3, CNTF, GDNF, MCP-1, VEGF, FGF-2, PDGF-AA and PDGF-AB/BB, MMP-9, ANG, TIMP-1, -4 |
|
| ||||
| Stem Cells from Apical Papilla (SCAP) | CD90, CD73, CD105, CD146, STRO-1, CD106, CD29, CD49, CD51, CD61, CD166, ALDH1, 3G5, CD44, CD9, CD10 CD13, CD59, MSCA-1, CD34, CD81, CD24, c-Kit CD271/NGFR, Nestin, NSE, CNPase, musashi-1, p75, snail-1, -2, slug, Sox-9 Nanog, Oct3/4, SSEAs (-1, -3, -4, -5), TRA-1-60-, TRA-1-81, Notch -2, -3 |
CD14 CD18 CD34 CD45 CD117 CD150 |
ANGPT-1, ANG, DPPIV, EDN-1, PTX-3, PEDF (serpin F1), IGFBP-1, -2, -3, TIMP-1, -4, TSP-1, VEGF, uPA, Activin A, HGF, FGF-7, PIGF (serpin E1), TGFb, CXCL-16, persephin, NRG1-b1, MCP-1 | MDK, NEGF-1 (PTN), NEGF-2, CXCR4, MANF, AHNAK, NRP2, ANG, TIMP-1, -4, CXCL-16, NRG1-b1, MCP-1 |