Table 1.

Mutations described in ATP1A2 gene related to FHM.

Mutation	Phenotypic characteristics
D718N [1]	Long-lasting hemiplegic migraine, seizures, and mental retardation
P979L [1]	Recurrent coma, seizures, mental retardation, and interictal mild cerebellar signs
R689Q [2]	Benign familial infantile convulsions
K7940 [2]	Spectrum between alternating hemiplegia of childhood (AHC) and FHM
A1033G, T345A [3]	Coma
E700K [2]	FHM
R593W and V628M [4]	FHM
M731T and T376M [5]	Pure FHM
A606T, N717K, R1002Q [6]	Severe hemiplegia
T415M [7]	Dysphasia and drowsiness and attacks triggered by mild head injury
V362E [8]	Mood alterations, classified as a borderline personality
P796S [8]	Mild mental impairment, in addition to hemiplegic migraine
D999H [8, 9]	Seizures
G900R [8]	Coma, high fever, and status epilepticus
G301R [10, 11]	FHM with interictal cerebellar symptoms
R548C [12]	Epilepsy
G855R [13]	Febrile seizures
G902L [14]	Fever, coma, and cortical edema in MR
V338A, Q927P [11]	Coma
G715R [15]	Aphasia, coma, and brain edema
R548H [16]	Hemiplegic migraine associated with basilar migraine
M731T [17]	Psychotic aura symptoms
p.T364M [18]	Prolonged hemiplegia, aphasia, somnolence, and fever in a child
R1007W [19]	Drowsiness with myoclonic seizures
S220L, R908Q [20]	Coma and aphasia
M731T [21]	Psychotic aura
R908Q [22]	FHM with prolonged aura
p.A348p [23]	Large family and severe and long-lasting attacks with coma and fever
c.G571A [24]	Neurosensorial hearing loss