Table 3.
Terminology systems that uniquely identify the genomically targeted antineoplastic drug vemurafeniba
| Terminology short name | Terminology long name (if applicable) | Definition | Unique code | Website |
|---|---|---|---|---|
| ATC | Anatomical Therapeutic Chemical classification system | vemurafenib | L01XE15 | http://www.whocc.no/atc_ddd_index/ |
| CAS Registry Number | Chemical Abstracts Service Registry Number | vemurafenib | 918504-65-1 | http://ww.cas.org/content/chemical-substances |
| ChEBI | Chemical Entities of Biological Interest | vemurafenib | CHEBI:63637 | https://www.ebi.ac.uk/chebi/ |
| ChEMBL | vemurafenib | CHEMBL1229517 | https://www.ebi.ac.uk/chembl/ | |
| ChemSpider | vemurafenib | 24747352 | http://www.chemspider.com | |
| DrugBank | vemurafenib | DB08881 | http://www.drugbank.ca | |
| eMolecules | vemurafenib | 32176418 | https://www.emolecules.com | |
| FDA UNII Code | Food and Drug Administration Unique Ingredient Identifier | vemurafenib | 207SMY3FQT | https://fdasis.nlm.nih.gov/srs/srs.jsp |
| Guide to Pharmacology | IUPHAR/BPS Guide to Pharmacology | vemurafenib | 5893 | http://www.guidetopharmacology.org |
| InChI | IUPAC International Chemical Identifier | vemurafenib | GPXBXXGIAQBQNI-UHFFFAOYSA-N | https://iupac.org/who-we-are/divisions/division-details/inchi/ |
| KEGG DRUG | Kyoto Encyclopedia of Genes and Genomes | vemurafenib | D09996 | http://www.genome.jp/kegg/drug/ |
| MeSH | Medical Subject Headings | PLX4032 | C551177 | https://www.ncbi.nlm.nih.gov/mesh |
| NCI Thesaurus | National Cancer Institute Thesaurus | vemurafenib | C64768 | https://ncit.nci.nih.gov/ncitbrowser/ |
| NCI-GLOSS | NCI Dictionary of Cancer Terms | PLX4032 | CDR0000670004 | https://www.cancer.gov/publications/dictionaries/cancer-terms |
| PDBe | Protein Data Bank in Europe | PLX4032 | 32 | http://www.ebi.ac.uk/pdbe/ |
| PDQ | Physician Data Query | vemurafenib | CDR0000528954 | https://www.cancer.gov/publications/pdq |
| PubChem | vemurafenib | CID:42611257 | https://pubchem.ncbi.nlm.nih.gov | |
| RxNorm | vemurafenib | RxCUI:1147220 | https://www.nlm.nih.gov/research/umls/rxnorm/ | |
| SNOMED-CT_US | Systematized Nomenclature of Medicine - Clinical Terms, US Realm | Vemurafenib (product) | SCTID:703656005 | https://www.nlm.nih.gov/healthit/snomedct/us_edition.html |
| UMLS | Unified Medical Language System | vemurafenib | C1832009 | https://www.nlm.nih.gov/research/umls/ |
| ZINC | vemurafenib | ZINC52509366 | http://zinc15.docking.org |
aWhile these 21 distinct terminologies may not be exhaustive, they do illustrate the challenge of using terminology bindings in standards. Similar complexity is observed in terminologies for diseases, genes, proteins, and pathways (see Additional file 1)