Table 4.
Estimated genetic effect and AUC from 1,000 simulations for various models and study designs
| Model simulated | Cohort, no interaction | Cohort, interaction | case-control, no interaction | case-control, interaction | ||||
|---|---|---|---|---|---|---|---|---|
| Model testeda | Est (SD) | AUC (SD) | Est (SD) | AUC (SD) | Est (SD) | AUC (SD) | Est (SD) | AUC (SD) |
| G | 0.127 (0.012) | 0.591 (0.009) | 0.121 (0.012) | 0.588 (0.009) | 0.129 (0.020) | 0.592 (0.013) | 0.124 (0.020) | 0.589 (0.013) |
| G+A | 0.127 (0.012) | 0.609 (0.008) | 0.121 (0.012) | 0.604 (0.009) | NA | NA | NA | NA |
| G+A+I | NA | NA | 0.164 (0.020) | 0.601 (0.009) | NA | NA | 0.171 (0.034) | 0.576 (0.012) |
| Tert1 | 0.127 (0.025) | 0.591 (0.017) | 0.165 (0.024) | 0.610 (0.016) | 0.133 (0.043) | 0.592 (0.027) | 0.173 (0.039) | 0.611 (0.025) |
| Tert2 | 0.126 (0.023) | 0.591 (0.015) | 0.125 (0.020) | 0.592 (0.015) | 0.130 (0.034) | 0.592 (0.023) | 0.133 (0.036) | 0.594 (0.023) |
| Tert3 | 0.127 (0.020) | 0.591 (0.013) | 0.089 (0.014) | 0.561 (0.014) | 0.131 (0.029) | 0.592 (0.019) | 0.091 (0.014) | 0.561 (0.020) |
Abbreviation: Est, average of estimated genetic effect of the 15 SNPs.
a
For all models, estimates are derived in a first sample using a fix set of parameters, AUC are then derived in a second sample generated using the same set of parameters but using the estimates obtained from the first sample. In model G, only the SNP effects are estimated; in model G+ A, effect of the SNPs and age are estimated jointly; in model G +A +I, SNP, age and SNP by age interaction are estimated; in model Tertn, SNP effects are estimated within each age tertile.