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. Author manuscript; available in PMC: 2017 Jan 15.
Published in final edited form as: Exp Cell Res. 2016 Jan 11;340(2):305–314. doi: 10.1016/j.yexcr.2016.01.004

Fig. 7.

Fig. 7

Proposed mechanism by which kallistatin induces breast cancer cell death. Kallistatin via its active site down-regulates miR-21 and miR-203 expression, and up-regulates miR-34a and SOCS3 expression. The heparin-binding domain is essential for kallistatin's ability to increase PPARγ expression via inhibition of Wnt signaling, and further induce autophagy. SOCS3, suppressor of cytokine signaling 3.