Table 3.
Effect of 1–11 on superoxide anion generation and elastase release in fMLP/CB induced human neutrophils.
| Compound | Superoxide Anion | Elastase Release |
|---|---|---|
| IC50 (μM) a | IC50 (μM) a | |
| 1 | >10 *** | >10 |
| 2 | 4.43 ± 0.23 *** | >10 *** |
| 3 | 2.76 ± 0.92 *** | >10 * |
| 4 | >10 | 6.80 ± 0.18 *** |
| 5 | >10 | >10 *** |
| 6 | >10 | >10 |
| 7 | >10 | >10 |
| 8 | >10 | >10 |
| 9 | >10 | >10 |
| 10 | >10 | >10 |
| 11 | >10 | >10 *** |
a Concentration necessary for 50% inhibition (IC50). Results are presented as mean ± S.E.M. (n = 3–5). * p < 0.05, *** p < 0.001 compared with the control.