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. 2016 Oct 17;14(10):187. doi: 10.3390/md14100187

Figure 7.

Figure 7

Effect of 11-dehydrosinulariolide on DJ-1 expression in a 6-OHDA-induced rat model of PD. Rats were treated with 5 μg/kg 11-dehydrosinulariolide (concentration 0.5 μg/μL for 10 μL), 20 μg 6-OHDA plus 11-dehydrosinulariolide and 11-dehydrosinulariolide alone for 14 days. The immunofluorescence staining of TH (green) (A–D) and DJ-1 (red) (E–H) in rat brains after 6-OHDA administration and 11-dehydrosinulariolide treatment, showing brains from the control (I); 6-OHDA-treated (J); 6-OHDA plus 11-dehydrosinulariolide-treated groups (K); and 11-dehydrosinulariolide alone (L) (n = 3). Treatment with 11-dehydrosinulariolide significantly increases expression of DJ-1 colocalized with TH, which is induced by 6-OHDA administration (scale bar = 100 μm).