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. 2016 Oct 27;8:111. doi: 10.1186/s13148-016-0273-7

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© The Author(s). 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 4 — Dendrograms depicting DML when comparing smokers and nonsmokers. Because absolute differences in methylation (i.e., beta values) between cases were small, these heatmaps illustrate relative differences in methylation between cases instead of absolute beta values. a smokers vs. nonsmokers, all cases (BE, LGD, HGD, and EAC) combined. b Smokers vs. nonsmokers, BE cases. c Smokers vs. nonsmokers, HGD/EAC cases