Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2016 Oct 27;8:111. doi: 10.1186/s13148-016-0273-7

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s). 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

PMC Copyright notice

Fig. 5 — Genomic location, relationship to CpG islands, and methylation status of DML when comparing smokers and nonsmokers in esophageal samples. “Hypo” refers to percentage of DML that are hypomethylated in smokers vs. nonsmokers; “Hyper” refers to percentage of DML that are hypermethylated in smokers vs. nonsmokers. On the Y axis, DMLs (%) refers to the percentage of the total DML that are associated with a particular genomic location (a, d) or CGI relationship (b, e). Percentages may up to more than 100 % because some probes were classified with more than one designation. Beta values are equivalent to percent methylation. Note: for all regions, the distribution of hypo/hypermethylated DML compared to the expected distribution (based on all array probes) was not statistically significant. a DML when comparing smoker to nonsmoker BE cases by genomic region. b Location of DML when comparing smoker to nonsmoker BE cases with respect to CpG island location. c Box and whisker plots showing distribution of DML that are hypomethylated in the smoker vs. nonsmoker BE cases (left) and hypermethylated in the smoker vs. nonsmoker BE cases (right). d DML when comparing smoker vs. nonsmoker HGD/EAC cases by genomic region. e Location of DML when comparing smokers vs. nonsmoker HGD/EAC cases with respect to CpG island location. f Box and whisker plots showing distribution of DML that are hypomethylated in the smoker vs. nonsmoker BMI HGD/EAC cases (left) and hypermethylated in the smoker vs. nonsmoker HGD/EAC cases (right)