Table 2.
Differentially methylated loci: high BMI vs. low BMI cases separated by tissue type
| Tissue | Total number of DML | Promoter DML (%) | Intragenic DML (%) | Intergenic DML (%) | CpG island DML (%) | CpG shore DML (%) | Cancer-associated DML (%) |
|---|---|---|---|---|---|---|---|
| BE | 288 | 85 (29 %) | 129 (45 %) | 74 (26 %) | 113 (39 %) | 108 (37 %) | 60 (21 %) |
| LGD | 372 | 120 (32 %) | 166 (45 %) | 86 (23 %) | 226 (61 %) | 166 (45 %) | 252 (68 %) |
| HGD/EAC | 270 | 73 (27 %) | 156 (58 %) | 41 (15 %) | 53 (20 %) | 111 (41 %) | 40 (15 %) |
DML defined by p value <0.001 and Δβ value (high BMI vs. low BMI) > 0.10 while controlling for age