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. 2016 Oct 21;8(10):97. doi: 10.3390/cancers8100097

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© 2016 by the authors; licensee MDPI, Basel, Switzerland.

This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).

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The structural domains of TAM receptors and ligands. Representation of the domain organization of the three TAM receptors: Tyro3, Axl and Mer at the plasma membrane of cells (a). TAM ligands: growth arrest-specific gene 6 (Gas6) and Protein S (Pros 1) are soluble circulating proteins (b). TAM receptors use their immunoglobulin-like (Ig-like) domains to bind the laminin G (LG) domains in the sex hormone binding globulin (SHBG) region of TAM ligands. PTK: Protein tyrosine kinase domain; FNIII: fibronectin type III domains; Gla: gamma-carboxyglutamic acid-rich domain; EGF-like: epidermal growth factor-like domain.