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. 2016 Jul 15;20(11):2194–2207. doi: 10.1111/jcmm.12926

Figure 6.

Figure 6

Effect of expression of R321X on both real time evaluation of ER calcium release/capacitative Ca2+ entry. (A) Time course of changes of [Ca2+]cyt before, during, and after application of 20 μM CPA in the absence (0 Ca2+) or presence of extracellular Ca2+ (2.0 mM) in Fura‐2 loaded HEK293 cells expressing either mCh‐Lamin A (black trace) or mCh‐R321X (grey trace). (B) Summarized data of the amplitude of CPA‐induced Ca2+ release in the absence of extracellular Ca2+, and amplitude of CPA‐induced capacitative Ca2+ entry. mCh‐Lamin A, black bars; mCh‐R321X, grey bars. Data are expressed as mean ± S.E.. Statistical analysis was performed on three independent experiments and significance calculated by Student's t‐test for unpaired samples. ***P < 0.001 versus mCh‐Lamin A.