Table 3.
Frequencies of the genotypes of rs3792267 (CAPN10), rs1501299 (APM1) and rs3760776 (FUT6) in T2DM patients and controls
| SNP | Genotype | T2DM no. (%) | Control no. (%) | P * | Logistic regression analysis (adjusted for age, gender and BMI)† | |||
|---|---|---|---|---|---|---|---|---|
| Dominant | Recessive | |||||||
| P | OR (95% CI) | P | OR (95% CI) | |||||
| rs3792267 (CAPN10) | GG | 82 (63.1%) | 108 (80%) | 0.006 | 0.002 | 2.51 (1.42–4.46) | 0.204 | 2.55 (0.60–10.82) |
| GA | 42 (32.3%) | 25 (18.5%) | ||||||
| AA | 5 (3.8%) | 2 (1.5%) | ||||||
| rs1501299 (APM1) | GG | 85 (65.4) | 69 (51.1) | 0.034 | 0.009 | 0.51 (0.31–0.85) | 0.732 | 0.91 (0.54–1.53) |
| GT | 39 (30) | 56 (41.5) | ||||||
| TT | 5 (3.8) | 8 (5.9) | ||||||
| rs3760776 (FUT6) | CC | 102 (78.5) | 94 (69.6) | 0.113 | 0.049 | 0.56 (0.31–0.99) | 0.211 | 0.33 (0.06–1.86) |
| CT | 26 (20) | 36 (26.7) | ||||||
| TT | 2 (1.5) | 5 (3.7) | ||||||
*The P‐values for comparison of statistically difference among the three genotypes for certain SNP between T2DM and control subjects. †The logistic regression model was used to obtain the odds ratios of the minor allele with the major allele as reference group. The P‐values with statistical significance are indicated in bold numbers.