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. Author manuscript; available in PMC: 2017 Oct 1.
Published in final edited form as: Top Magn Reson Imaging. 2016 Oct;25(5):197–204. doi: 10.1097/RMR.0000000000000105

Figure 6. Schematic showing the principles of in vivo detection of cell viability using LipoCEST microcapsules as pH nanosensors.

Figure 6

The CEST contrast is measured by the drop in the signal intensity (ΔS) of water after selective saturation (i.e. removal of capability to generate signal) of the NH protons in L-arginine at 2 ppm. The L-arginine protons (red) inside the LipoCEST capsules exchange (kSW) with the surrounding water protons. The kSW is reduced at lower pH causing a significant drop in CEST contrast. Reproduced from (9) with permission.