Table 1.

Summary of Models Discussed

Type of model/injury	Species	Intervention	In vivo or in vitro	Effect of intervention on liver	Reference
Viral hepatitis	Mouse	Platelet depletion	In vivo	Hepatoprotective	47
Viral hepatitis	Mouse	Inhibition of platelet activation	In vitro and in vivo	Hepatoprotective	12, 13, 48, 49, 50, 51
Viral hepatitis	Mouse	Blocking platelet binding to endothelium	In vitro and in vivo	Variable can be either hepatoprotective or hepatotoxic	5, 12
Isolated HSEC coculture with platelets	Human	Blocking platelet binding to endothelium	In vitro	Hepatoprotective (reduced effector cell recruitment)	5
Ischemia‐reperfusion	Mouse	Blocking platelet‐Kupffer cell interaction	In vivo	Hepatoprotective (reduction in steatosis)	42, 45, 46
Thermal injury	Mouse	Blocking platelet binding	In vivo	Hepatotoxic (reduced neutrophil‐mediated repair)	30
Acute cholestasis	Mouse	Inhibition of platelet activation	In vivo	Hepatoprotective	58, 59, 60
Chronic cholestasis	Mouse	Platelet depletion/inhibition of platelet activation	In vivo	Hepatotoxic (worsens fibrosis)	62, 63