Fig. 3.

Negative correlation between the modulation of right insula–anterior cingulate cortex (ACC) connectivity and unusual thought content across untreated (r = −0.593, p = 0.012), but not treated (r = 0.127, p = 0.70) patients with first-episode psychosis (FEP). The X axis represents patients’ unusual thought content as indexed by the Brief Psychiatric Rating Scale item 11. The Y axis represents the posterior mean (1/s) of the modulation of right insula–ACC connectivity induced by high-probability reward cues.