. 2016 Sep 19;44(10):1039–1050. doi: 10.1111/apt.13794

Table 3.

Age at presentation (‘Age’) and relationship with each quality of life domain adjusted for gender, albumin ratio, UDCA response and disease duration

	${\hat{β}}_{i}$ (S.E.)	t value	P value	R ²
PBC‐40 itch
Age^−0.5 (10 unit increase)	16.13 (3.09)	5.21	<0.001	0.06
Male	−0.95 (0.50)	−1.91	0.06
Albumin ratio	−1.06 (0.81)	−1.31	0.19
UDCA response	−1.10 (0.35)	−3.16	<0.01
Duration	−0.01 (0.03)	−0.40	0.69
PBC‐40 symptoms
Age (10 unit increase)	−0.78 (0.17)	−4.63	<0.001	0.06
Male	−2.88 (0.58)	−4.98	<0.001
Albumin ratio	−1.56 (0.95)	−1.65	0.10
UDCA response	0.36 (0.41)	0.88	0.38
Duration	0.06 (0.03)	1.82	0.07
PBC‐40 fatigue
Age (10 unit increase)	−1.49 (0.34)	−4.34	<0.001	0.05
Male	−4.30 (1.17)	−3.67	<0.001
(Albumin ratio)⁻²	5.92 (1.59)	3.71	<0.001
UDCA response	0.03 (0.83)	0.03	0.97
Duration	0.04 (0.06)	0.65	0.52
PBC‐40 cognitive
Age (10 unit increase)	−0.71 (0.20)	−3.61	<0.001	0.02
Male	−1.03 (0.68)	−1.51	0.13
Albumin ratio	−1.65 (1.10)	−1.50	0.13
UDCA response	−0.46 (0.48)	−0.95	0.34
Duration	0.01 (0.04)	0.30	0.76
PBC‐40 emotional
Age (10 unit increase)	−0.66 (0.11)	−6.16	<0.001	0.06
Male	−0.96 (0.37)	−2.62	<0.01
Albumin ratio	−1.92 (0.60)	−3.21	<0.01
UDCA response	0.01 (0.26)	0.02	0.98
Duration	−0.02 (0.02)	−1.20	0.23
PBC‐40 social
Age (10 unit increase)	−1.24 (0.30)	−4.17	<0.001	0.04
Male	−1.42 (1.02)	−1.40	0.16
(Albumin ratio)⁻²	4.48 (1.39)	3.23	<0.01
UDCA response	−1.13 (0.72)	−1.57	0.12
Duration	0.07 (0.05)	1.40	0.16
ESS sleep
Age³ (10 unit increase)	−0.10 (0.03)	4.89	<0.001	0.03
Age³log(age) (10 unit increase)	0.04 (0.01)
Male	0.38 (0.54)	0.72	0.47
Albumin ratio	−0.74 (0.87)	−0.85	0.39
UDCA response	−0.58 (0.38)	−1.53	0.13
Duration	−0.03 (0.03)	−1.16	0.25
OGS autonomic
Age³ (10 unit increase)	−0.05 (0.02)	3.05	<0.01	0.02
Age³log(age) (10 unit increase)	0.03 (0.01)
Male	−0.94 (0.36)	−2.63	<0.01
Albumin ratio	−0.34 (0.58)	−0.58	0.56
UDCA response	0.16 (0.25)	0.62	0.53
Duration	0.02 (0.02)	1.09	0.28
HADS anxiety
Age (10 unit increase)	−0.64 (0.14)	−4.59	<0.001	0.04
Male	−1.94 (0.48)	−4.06	<0.001
Albumin ratio	−0.27 (0.78)	−0.35	0.72
UDCA response	0.31 (0.34)	0.92	0.36
Duration	−0.03 (0.02)	−1.05	0.29
HADS depression
Age (10 unit increase)	−0.39 (0.12)	−3.32	<0.001	0.03
Male	−0.37 (0.40)	−0.90	0.37
(Albumin ratio)⁻²	1.78 (0.55)	3.23	<0.01
UDCA response	−0.37 (0.29)	−1.30	0.19
Duration	0.01 (0.02)	0.47	0.64