Table 5. Multiple sequence alignments of sulfotransferases showing conservation of amino acid residues mutated in Turkish MCD patients.
| Sulfotransferase | F55V | V176M | P204S | R211W | C246W |
|---|---|---|---|---|---|
|
CHST6 (human) |
SFVG |
EVRF |
DPRA |
SREQ |
VCRS |
|
CHST5 (human) |
SFLG |
EVRF |
DPRA |
SREA |
VCRS |
|
CHST4 (human) |
SFVG |
EVRF |
DPRA |
SRER |
ICQS |
|
CHST3 (human) |
SFVG |
AVRI |
DPRA |
SR– |
NCES |
|
CHST2 (human) |
SFFG |
GVRF |
DPRA |
SRIR |
ICNS |
|
CHST5 (mouse) |
SFVG |
EVRF |
DPRA |
SREQ |
VCRS |
|
CHST4(mouse) |
SFVQ |
EVRF |
DPRA |
SREH |
ICKS |
|
CHST3(mouse) |
SFFG |
AVRI |
DPRA |
SR-I |
NCES |
| CHST2(mouse) | SFVG | GVRV | DPRA | SRIR | ICNS |