Table 1. Thinning of the ONL and retina of the IRBP KO relative to the WT.
| Age |
Total Retina Thickness
Mean ± standard deviation |
Two-way ANOVA with Tukey’s test |
Photoreceptor Thickness
Mean ± standard deviation |
Two-way ANOVA with Tukey’s test | ||
|---|---|---|---|---|---|---|
| WT (n=5) | KO (n=10) | WT (n=5) | KO (n=10) | |||
|
P15-P17 |
227.88±3.87 |
200.92±10.21 |
**** |
88.10±1.42 |
76.72±3.75 |
**** |
| |
WT (n=5) |
KO (n=8) |
|
WT (n=5) |
KO (n=8) |
|
|
P30 |
220.19±3.63 |
166.30±3.89 |
**** |
97.81±3.53 |
64.14±2.33 |
**** |
| |
WT (n=6) |
KO (n=8) |
|
WT (n=6) |
KO (n=8) |
|
|
P45 |
218.61±5.65 |
166.59.88±3.55 |
**** |
99.24±4.82 |
63.62±1.47 |
**** |
| |
WT (n=5) |
KO (n=7) |
|
WT (n=5) |
KO (n=7) |
|
| P80-P81 | 215.09±2.72 | 163.97±3.26 | **** | 101.95±4.00 | 62.63±1.68 | **** |
Total retinal thicknesses and photoreceptor cell layer (ONL+IS+OS) thicknesses were measured with a Micron IV SD-OCT in WT and KO mice (P15-P80). The present measurements were taken in a ring around the optic nerve head at about 100 microns radially, indicating a loss throughout regardless of vertical or horizontal orientation. Values are reported in microns. Comparisons were made by ANOVA and Tukey test. **** Represents p<0.0001.