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. 2016 Oct 26;12(10):e1005972. doi: 10.1371/journal.ppat.1005972

Fig 3. Type 2 diabetes increases pro- and anti-inflammatory responses during Mtb infection.

Fig 3

Control and T2DM mice were infected with 50–100 CFU of aerosolized Mtb H37Rv. A. At 1 and 6 months p.i., lung homogenates from uninfected control and T2DM, and Mtb-infected control and T2DM, mice were collected and cytokine and chemokine levels were measured in a multiplex ELISA. Data are representative of two independent experiments (n = 5 mice per group per experiment). B. At 6 months p.i., lungs from uninfected control and diabetic mice and from Mtb-infected control and Mtb-infected diabetic mice were isolated and formalin-fixed. Paraffin-embedded tissue sections were prepared, and hematoxylin and eosin staining was performed. Inflamed lung areas were compared between groups. A representative figure is shown. Data are representative of two independent experiments (n = 5 mice per group per experiment). Data are expressed as the mean ± SE. *P < 0.05, **P < 0.01, and ***P < 0.001.