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. Author manuscript; available in PMC: 2016 Oct 27.
Published in final edited form as: Nature. 2016 Feb 17;531(7593):220–224. doi: 10.1038/nature16957

Figure 3. Transannular C–H arylation of 3-azabicyclo[3.1.0]hexane core.

Figure 3

a, Scope of C–H arylation with respect to the aryl iodide. b, Relevant steps in overall transformation: installation of directing group, C–H arylation and SmI2-mediated removal of directing group (Aryl = biphenyl). PivCl, pivaloyl chloride; TEA, triethylamine. c, C–H arylation applied to amitifiadine. All yields are reported for pure isolated material. †, Reaction was conducted using 20 equiv of PhBr; yield determined by GC. ‡, Reaction was conducted under modified conditions. See supplementary information for full details.