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. Author manuscript; available in PMC: 2016 Oct 27.
Published in final edited form as: Nature. 2016 Feb 17;531(7593):220–224. doi: 10.1038/nature16957

Figure 4. Transannular C–H arylation of alicyclic amines.

Figure 4

a, Scope of the C–H arylation reaction with respect to the amine. b, Application of this reaction to the derivatization of varenicline. c, Application of this reaction to the derivatization of cytisine. Yields are reported for pure isolated products. †, Reaction was conducted under modified conditions. See supplementary information for full details.