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. Author manuscript; available in PMC: 2018 Jan 1.
Published in final edited form as: Neuropharmacology. 2016 Sep 20;112(Pt A):11–15. doi: 10.1016/j.neuropharm.2016.08.034

Figure 3. Pharmacological properties and auxiliary proteins.

Figure 3

iGluRs harbor multiple binding sites for small molecules acting as allosteric modulators and for auxiliary proteins that modulate receptor trafficking and activity. The left panel shows how NMDA receptors have binding pockets on ATD, LBD and TMD layers. The right panel shows that AMPA/kainate receptors have binding cavities between the ATD-LBD layer, within the LBD dimer interface, and within the TMDs for both small molecules and proteins.