Table 1.

Test Performance Characteristics (Serial Alpha-fetoprotein, Age, Alanine Aminotransferase, and Platelets) Model Estimated 6-month HCC Probabilities at Various Risk Thresholds Generated by the Model

Predicted HCC Probability Threshold (%)	Sensitivity (%)	Specificity (%)	NPV (%)	PPV (%)
4	68.2	83.3	98.4	14.5
10	49.5	96.0	97.9	34.1
20	40.0	98.4	97.5	51.1
30	36.0	99.1	97.4	61.1
40	31.0	99.4	97.2	66.7
50	26.4	99.5	97.0	70.6
60	21.5	99.68	96.8	73.5
70	16.3	99.8	96.6	77.6
80	10.2	99.9	96.4	82.8
90	4.9	99.9	96.2	87.1

HCC, hepatocellular carcinoma; NPV, negative predictive value; PPV, positive predictive value.