Table 2.

Regions contributing to the α4β2 disease–related pattern with high confidence (|Z| ≥ 1.64, p ≤ 0.05) in AD

Hemisphere	MNI coordinates	Region	Z score
	4, −29, −28	Pedunculopontine nucleus	−2.2
L	−8, 8, −12	Nucleus accumbens	−1.9
R	12, 8, −12	Nucleus accumbens	−2.0
L	−24, −12, −24	Hippocampus	−2.3
R	28, −12, −20	Hippocampus	−1.7
L	−20, −4, −20	Amygdala	−1.9
R	28, 0, −20	Amygdala	−1.8
L	−16, 16, −20	Orbitofrontal cortex	−1.9
R	24, 12, −20	Orbitofrontal cortex	−2.3
L	0, 36, −16	Medial frontal cortex	−2.1
R	4, 36,−16	Medial frontal cortex	−2.0
L	−28, 20, −8	Insula	−1.7
R	44, 12, −4	Insula	−2.5
L	−52, 24, 4	Inferior frontal gyrus	−2.0
R	56, 16, 4	Inferior frontal gyrus	−2.2
L	−8, −20, 16	Thalamus	−2.5
R	12, −20, 16	Thalamus	−2.9
L	−4, 8, 36	Anterior cingulate	−3.3
R	4, 32, 16	Anterior cingulate	−2.3
L	0, −44, 32	Posterior cingulate	−2.0
R	4, −32, 32	Posterior cingulate	−1.8
L	−48, −48, 44	Inferior parietal	−2.2
R	52, −60, 48	Inferior parietal	−1.7
L	−4, −72, 52	Precuneus	−1.9
R	4, −48, 64	Precuneus	−1.9
R	16, 8, −8	Putamen	−1.9
L	−12, −60, −36	Posterior cerebellum	2.4
R	20, −56, −36	Posterior cerebellum	2.8
L	−12, −60, −24	Anterior cerebellum	2.3
R	20, −56, −24	Anterior cerebellum	2.6
L	−12, −16, −10	Midbrain	2.0
R	18, −18, −10	Midbrain	2.0
L	−20, −12, 0	Pallidum	2.1
R	24, −12, 0	Pallidum	2.0
L	−40, −72, 12	Middle occipital gyrus	2.5
R	36, −84, 16	Middle occipital gyrus	2.9
L	−12, −88, 16	Cuneus	2.8
R	20, −84, 16	Cuneus	2.7
L	−48, −16, 32	Postcentral gyrus	2.2
R	52, −12, 32	Postcentral gyrus	2.5
L	−44, −4, 36	Precentral gyrus	2.0
R	52, −4, 36	Precentral gyrus	1.8

Key: AD, Alzheimer's disease; L, left; MNI, Montreal Neurological Institute; R, right.