Table 5. Comparison of genetic versus non-genetic model for 10% weight gain prediction at one year after transplantation.
AUROC [95% CI] | Specificity | Sensitivity | Accuracy | LRT-p | IDI [95% CI]* | NNG | ||
---|---|---|---|---|---|---|---|---|
Sample A | SNP group#1 | |||||||
non genetic model | 0.66 [0.58–0.72] | 0.59 | 0.66 | 0.61 | 0.0004 | 0.08 [0.06–0.10] | 24 | |
genetic model | 0.74 [0.70–0.83] | 0.61 | 0.77 | 0.65 | ||||
SNP group#2 | ||||||||
non genetic model | 0.66 [0.54–0.69] | 0.65 | 0.62 | 0.64 | 0.008 | 0.17 [0.14–0.20] | 13 | |
genetic model | 0.80 [0.71–0.84] | 0.70 | 0.77 | 0.72 | ||||
Sample B | SNP group#1 | |||||||
non genetic model | 0.67 [0.61–0.88] | 0.55 | 0.76 | 0.63 | 0.04 | 0.36 [0.28–0.45] | 6 | |
genetic model | 0.89 [0.79–0.97] | 0.78 | 0.88 | 0.81 |
AUROC: Area Under the Receiver Operating Characteristic Curve
IDI: Integrated Discrimination Improvement
NNG: Number Needed to Genotype
LRT: Likelihood Ratio tests
SNP: Single Nucleotide Polymorphism
CI: Confidence Interval
*p-value < 0.01