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. 2016 Oct 27;11(10):e0165422. doi: 10.1371/journal.pone.0165422

Fig 1. Indicators for atherosclerotic development in the rabbit model.

Fig 1

Bi-dimensional mode echographic view of the ascending aorta (Asc. Aorta) in (A) a non-atherosclerotic (non-cholesterol-fed) animal vs. in (B) an atherosclerotic (cholesterol-fed animal) showing an atheromatous plaque (between the arrows) and increased intima-media thickness (IMT). (C) Morphology of the aorta in non-atherosclerotic vs. (D) atherosclerotic rabbit with infiltration of the intima by foam cells (FC). (E) Echographic measurements of the aortic IMT in the non-atherosclerotic vs. atherosclerotic animals, mean ± standard deviation (both n = 15), analyzed using unpaired t-test, ****p<0.0001. (F) Serum lipids (TG: triglycerides, TC: total cholesterol, HDL-C: high-density lipoprotein-cholesterol, LDL-C: low-density lipoprotein-cholesterol) on completion of 6 weeks of feeding with normal (non-atherosclerotic) vs. 1% cholesterol-containing diet (atherosclerotic), mean ± standard deviation (both n = 15); analyzed using unpaired t-test, ***p<0.001.