Table 1. Potencies (log ED50) of selepressin, arginine vasopressin (AVP), and norepinephrine (NE) for hemodynamic parameters in non-atherosclerotic (NA) and atherosclerotic (A) rabbits.
HemodynamicParameter | Log ED50 (log(ng.kg-1.min-1)) | |||||
---|---|---|---|---|---|---|
Selepressin | AVP | NE | ||||
NA | A | NA | A | NA | A | |
DAP | −7.4±0.2 | −8.5±0.9 | −10.0±7.5 | −8.7±1.1 | −6.0±0.3 | −5.8±0.4 |
MAP | −7.2±0.3 | −8.5±1.3 | No fit | −8.6±1.4 | −6.1±0.3 | −5.7±0.3 |
SAP | −7.2±0.4 | No fit | −6.6±1.9 | −8.6±3.2 | −6.1±0.2 | −5.±0.2 |
HR | −7.6±0.3 | −7.4±0.2 | −8.6±0.2 | −8.5±0.5 | −6.9±0.9 | −7.0 ±1.2 |
ABF | −8.7±0.7 | −8.1±1.2 | −8.1±0.5 | −8.4±0.2 | −6.5±0.4 | −6.2±0.7 |
SV | −4.9±6.2 | −6.5±1.0 | −7.5±5.9 | −7.9±5.1 | −6.5±0.4 | −5.4±0.4 |
All values are mean ± standard error of the mean. Selepressin and AVP were statistically compared for hemodynamic effects by means of comparison of fits (extra-sum-of-squares F test). No fit: dose-response curve could not be statistically fitted. See legend of Fig 2 for the hemodynamic parameter abbreviations.