Table 2. Effect of BSO on fatty acid precursors and products of stearoyl coenzyme A desaturase 1.
| Control (N = 23) | BSO (N = 20) | BSO/ Control2 (%) | |
|---|---|---|---|
| Concentration in total plasma lipids | |||
| C16:0 (palmitic) | 3506 (3394, 3622) | 3019 (2801, 3152) | 86** |
| C16:1n-7 (palmitoleic) | 118 (107, 133) | 73.5 (59.8, 85.1) | 62** |
| C18:0 (stearic) | 1284 (1238, 1386) | 1267 (1170, 1341) | 99 |
| C18:1n9 (oleic) | 2581 (2310, 2892) | 1631 (1389, 1863) | 63** |
| Free fatty acid concentration | |||
| C16:0 (palmitic) | 513 (447, 531) | 405 (366, 470) | 79* |
| C16:1n-7 (palmitoleic) | 53.7 (45.0, 58.8) | 37.1 (32.5, 44.7) | 69** |
| C18:0 (stearic) | 133 (116, 153) | 132 (122, 173) | 99 |
| C18:1n9 (oleic) | 417 (343, 443) | 305 (285, 354) | 73** |
| Sum of free fatty acids3 | 1554 (1379, 1670) | 1230 (1094, 1450) | 79** |
1. Data represents median (25%, 75%). All concentrations are in μmol/L plasma, and are measured after an overnight fast.
*P<0.05;
**P<0.001, Mann Whitney U test. Stearoyl coenzyme A desaturase converts palmitic to palmitoleic, and stearic to oleic acids.
2. Calculated using medians.
3. Sum of all the free fatty acids reported in S1 Table.