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. 2016 Oct 27;11(10):e0165327. doi: 10.1371/journal.pone.0165327

Fig 4. Gene expression analysis in prepubertal and pubertal stages.

Fig 4

(A) The enriched pathways on the basis of different gene expression, as determined by GO analysis. (B) The enriched pathway on the basis of different gene expression, as determined by KEGG analysis. Rich factor refers to the ratio between the number of genes enriched in a pathway and annotated in DMR. Rich factor and enrichment are positively correlated. Q-value is the P-value that was corrected after multiple hypothesis testing. Q-value and enrichment are negatively correlated. (C) Five genes were detected, and their expression and methylation patterns were both altered during puberty onset. (D) Methylation level changes in DHRS3, NLRC5, CIB4, DOCK6 and SCO-spondin during prepubertal and pubertal stages. (E) The ratio of mRNA between prepubertal and pubertal stages. A positive ratio represents upregulation and a negative ratio represents downregulation. Prepub = prepuberty; Pub = puberty; BP = biological process; CC = cellular component; MR = molecular function; GO = gene ontology; KEGG = Kyoto Encyclopedia of Genes and Genomes; DMR = differentially methylated regions.