FIGURE 1.

Structural and functional organization of the Saccharomyces cerevisiae Sup35 protein. (A) Domain organization of Sup35. Designations N, M and C refer to the Sup35N (N-proximal), Sup35M (middle) and Sup35C (C-proximal) regions, respectively. Numbers correspond to amino acid positions. (B) Hypothetical model of tertiary structure of the non-prion isoform of Sup35. N domain is intrinsically unfolded, structure of M domain is unknown (shown as unfolded), the C domain structure is based on cryo-electron microscopy analysis (EMDB accession ID: 4crn).⁸⁹